TAB2 Rabbit Polyclonal Antibody

CAT#: TA319843

Rabbit Polyclonal TAB2 Antibody

Product Images

Immunohistochemistry of TAB2 in human brain tissue with TAB2 antibody at 5 ug/mL.

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 5 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: TAB2 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human TAB2.
• Formulation: TAB2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: TAB2 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: TGF-beta activated kinase 1/MAP3K7 binding protein 2
• Database Link:
  NP_055908
  Entrez Gene 23118 Human
  UniProt ID Q9NYJ8
• Background: TAB2 Antibody: TAB2 is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation NF-kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKL through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Recent experiments have shown that TAB2 and the related protein TAB3 constitutitvely interact with the autophagy mediator Beclin-1; upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibit autophagy, while their depletion triggers it, suggesting that TAB2 and TAB3 act as a control point for autophagy.
• Synonyms: CHTD2; MAP3K7IP2; TAB-2

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: MAPK signaling pathway, NOD-like receptor signaling pathway, Toll-like receptor signaling pathway