Lipin 1 (LPIN1) Rabbit Polyclonal Antibody

CAT#: TA319846

Rabbit Polyclonal LPIN1 Antibody

Product Images

Western blot analysis of LPIN1 in K562 cell lysate with LPIN1 antibody at 1 ug/mL.

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  Immunohistochemistry of LPIN1 in human small intestine tissue with LPIN1 antibody at 5 ug/mL.

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  Immunofluorescence of LPIN1 in human small intestine tissue with LPIN1 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: LPIN1 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human LPIN1.
• Formulation: LPIN Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: LPIN1 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 107 kDa; Observed: 125 kDa
• Gene Name: lipin 1
• Database Link:
  NP_001248356
  Entrez Gene 14245 MouseEntrez Gene 313977 RatEntrez Gene 23175 Human
  UniProt ID Q14693
• Background: LPIN1 Antibody: LPIN1, also known as PAP1, is a magnesium-ion-dependent phosphatidic acid phosphohydrolase enzyme that catalyzes the penultimate step in triglyceride synthesis including the dephosphorylation of phosphatidic acid to yield diacylglycerol (reviewed in 1). LPIN1 is required for adipocyte differentiation and it also functions as a nuclear transcriptional coactivator with some peroxisome proliferator-activated receptors to modulate expression of other genes involved in lipid metabolism (1,2). Mutations in LPIN1 are associated with metabolic diseases such as type 2 diabetes and recurrent acute myoglobinuria (3,4) and it is also a candidate for several human lipodystrophy syndromes (5).
• Synonyms: PAP1