C9orf116 Rabbit Polyclonal Antibody

CAT#: TA320108

Rabbit Polyclonal PIERCE1 Antibody

Product Images

Western blot analysis of PIERCE1 in A20 cell lysate with PIERCE1 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.

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  Immunocytochemistry of PIERCE1 in A20 cells with PIERCE1 antibody at 2.5 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: PIERCE1 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human PIERCE1.
• Formulation: PIERCE1 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: PIERCE1 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: chromosome 9 open reading frame 116
• Database Link:
  NP_653255
  Entrez Gene 138162 Human
  UniProt ID Q5BN46
• Background: PIERCE1 Antibody: PIERCE1, also known as C9orf116, is an important p53 target gene contributing to normal DNA damage response and may play crucial roles in maintaining genomic integrity against genotoxic stresses, including UVC irradiation. PIERCE1 exists as two alternatively spliced isoforms and is predominantly expressed in human small cell lung cancer. PIERCE1 knockdown induces down-regulation of proapoptotic genes including Ei24, Apaf1 and PTEN, suggesting that PIERCE1 is a proapoptotic gene. It is helpful for in-depth understanding of p53 pathways and the design of new cancer therapies.
• Synonyms: PIERCE1; RbEST47