CD95 Mouse Monoclonal Antibody [Clone ID: EOS9.1]

CAT#: TA320327

Mouse Anti-Human CD95 (APO-1/Fas) Purified

Product Images

The Jurkat cell line was treated for 6 hours with medium alone (left) or 0.1 ug/mL of Anti-Human CD95 (APO-1/Fas) Functional Grade Purified (right). Induction of apoptosis in these cells was determined by staining with Propidium Iodide and Anti-BrdU-FITC using the Apo-BrdU Apoptosis Detection Kit.

Specifications

Product Data

• Clone Name: EOS9.1
• Applications: FC
• Recommended Dilution: Flow, Functional Assay
• Reactivities: Human
• Host: Mouse
• Clonality: Monoclonal
• Formulation: Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
• Concentration: lot specific
• Purification: Affinity purified
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Database Link:
  NP_000034
  Entrez Gene 355 Human
• Background: The EOS9.1 monoclonal antibody reacts with human CD95 (Fas, Apo-1), a 40-50 kDa member of the TNFR superfamily. CD95 is expressed by a broad range of hematopoietic and non-hematopoietic cells including monocytes, neutrophils, activated lymphocytes and fibroblasts. Interaction of CD95 on mature lymphocytes with its ligand (FasL) induces apoptosis and is thought to be important in peripheral tolerance. EOS9.1 does not block binding of DX2, another antibody specific for human CD95.
• Synonyms: ALPS1A; APO-1; APT1; CD95; FAS1; FASTM; TNFRSF6

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein
• Protein Pathways: Allograft rejection, Alzheimer's disease, Apoptosis, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Graft-versus-host disease, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, p53 signaling pathway, Pathways in cancer, Type I diabetes mellitus