CD51 (ITGAV) Mouse Monoclonal Antibody [Clone ID: 23C6]

CAT#: TA320388

Mouse Anti-Human CD51/CD61 (Integrin alpha v beta 3) Purified (100 ug)

Product Images

Staining of platelets with 0.5 ug of Mouse IgG1 Isotype Control Purified (open histogram) or 0.5 ug of Anti-Human CD51/CD61 (Integrin alpha/beta 3) Purified followed by Anti-Mouse IgG FITC (filled histogram).

Specifications

Product Data

• Clone Name: 23C6
• Applications: FC
• Recommended Dilution: Flow, IHC
• Reactivities: Human
• Host: Mouse
• Clonality: Monoclonal
• Formulation: Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: integrin subunit alpha V
• Database Link:
  NP_002201
  Entrez Gene 3685 Human
  UniProt ID P06756
• Background: The 23C6 monoclonal antibody reacts with the human CD51/CD61 dimer, also known as the integrin αv/β3. CD51, an ~120 kDa surface molecule can also non-covalently associate with other β subunits of the integrin family including β1 (CD29), β5 and β6 to form receptors for extracellular matrix components. Heterodimers of CD51/CD61 are expressed by melanoma cells, endothelial cells and osteoclasts and at very low levels by platelets. The CD51/CD61 complex mediates adhesion to fibrinogen, fibronectin, vitronectin and thrombospondin.
• Synonyms: CD51; MSK8; VNRA; VTNR

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC), Cell adhesion molecules (CAMs), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hypertrophic cardiomyopathy (HCM), Pathways in cancer, Regulation of actin cytoskeleton, Small cell lung cancer