Neuropeptide Y (NPY) Rabbit Polyclonal Antibody

CAT#: TA321231

Anti-NPY Rabbit Polyclonal Antibody

Product Images

Gel: 12%SDS-PAGE Lysate: 40 μg Lane: Mouse adrenal gland tissue lysate Primary antibody: TA321231 (NPY Antibody) at dilution 1/1150 Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution Exposure time: 30 seconds

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1000-5000
  WB positive control: Mouse adrenal gland tissue lysate
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Full length fusion protein
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 11 kDa
• Gene Name: neuropeptide Y
• Database Link:
  NP_000896
  Entrez Gene 24604 RatEntrez Gene 109648 MouseEntrez Gene 4852 Human
  UniProt ID P01303
• Background: This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes; including cortical excitability; stress response; food intake; circadian rhythms; and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase; activate mitogen-activated protein kinase (MAPK); regulate intracellular calcium levels; and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels; higher alcohol consumption; and may be a risk factor for various metabolic and cardiovascular diseases.
• Synonyms: PYY4

Reference Data

• Protein Families: Druggable Genome, Secreted Protein, Transmembrane
• Protein Pathways: Adipocytokine signaling pathway