Annexin VII (ANXA7) Rabbit Polyclonal Antibody

CAT#: TA321292

Anti-ANXA7 Rabbit Polyclonal Antibody


USD 345.00

In Stock*

Size
    • 100 ul

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Specifications

Product Data
Applications ELISA, IHC
Recommended Dilution IHC: 50-200
Positive control: Human lung cancer
Predicted cell location: Cytoplasm, Cell membrane
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Fusion protein corresponding to C terminal 232 amino acids of Human Annexin A7
Formulation PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration lot specific
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name annexin A7
Background Annexin VII is a member of the annexin family of calcium-dependent phospholipid binding proteins.The Annexin VII gene contains 14 exons and spans approximately 34 kb of DNA. An alternatively spliced cassette exon results in two mRNA transcripts of 2.0 and 2.4 kb which are predicted to generate two protein isoforms differing in their N-terminal domain. The alternative splicing event is tissue specific and the mRNA containing the cassette exon is prevalent in brain; heart and skeletal muscle. The transcripts also differ in their 3'-non coding regions by the use of two alternative poly(A) signals. Annexin VII encodes a protein with a molecular weight of approximately 51 kDa with a unique; highly hydrophobic N-terminal domain of 167 amino acids and a conserved C-terminal region of 299 amino acids. The latter domain is composed of alternating hydrophobic and hydrophilic segments. Structural analysis of the protein suggests that Annexin VII is a membrane binding protein with diverse properties; including voltage-sensitive calcium channel activity; ion selectivity and membrane fusion.
Synonyms ANX7; SNX; SYNEXIN
Reference Data

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