VEGF Receptor 2 (KDR) Rabbit Polyclonal Antibody
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Specifications
Product Data | |
Applications | IHC, WB |
Recommended Dilution | WB: 200-1000 WB positive control: Rat brain tissue IHC: 50-200 Positive control: Human colon cancer Predicted cell location: Cytoplasm,Cell membrane |
Reactivities | Human, Mouse, Rat |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | Synthetic peptide corresponding to a region derived from 1163-1176 amino acids of human kinase insert domain receptor (a type III receptor tyrosine kinase) |
Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
Concentration | lot specific |
Purification | Antigen affinity purification |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 152 kDa |
Gene Name | kinase insert domain receptor |
Database Link | |
Background | Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor; known as kinase insert domain receptor; is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation; survival; migration; tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors; including Rab GTPase; P2Y purine nucleotide receptor; integrin alphaVbeta3; T-cell protein tyrosine phosphatase; etc.. Mutations of this gene are implicated in infantile capillary hemangiomas.? |
Synonyms | CD309; FLK1; VEGFR; VEGFR2 |
Reference Data | |
Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Transmembrane |
Protein Pathways | Cytokine-cytokine receptor interaction, Endocytosis, Focal adhesion, VEGF signaling pathway |
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