Nav1.5 (SCN5A) Rabbit Polyclonal Antibody

CAT#: TA321977

Anti-SCN5A Rabbit Polyclonal Antibody

Product Images

Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using TA321977 (SCN5A Antibody) at dilution 1/25 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using TA321977 (SCN5A Antibody) at dilution 1/25, treated with synthetic peptide. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 25-100
  Positive control: Human ovarian cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 1860-1874 amino acids of human sodium channel, voltage-gated, type V, alpha subunit
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: sodium voltage-gated channel alpha subunit 5
• Database Link:
  NP_000326
  Entrez Gene 20271 MouseEntrez Gene 25665 RatEntrez Gene 6331 Human
  UniProt ID Q14524
• Background: The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3); an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms.
• Synonyms: CDCD2; CMD1E; CMPD2; HB1; HB2; HBBD; HH1; ICCD; IVF; LQT3; Nav1.5; PFHB1; SSS1; VF1

Reference Data

• Protein Families: Druggable Genome, Ion Channels: Sodium, Transmembrane