HMGA1 Rabbit Polyclonal Antibody

CAT#: TA322034

Anti-HMGA1 Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 50-200
  Positive control: Human colon cancer
  Predicted cell location: Nucleus
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 12-24 amino acids of Human high mobility group AT-hook 1
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 12 kDa
• Gene Name: high mobility group AT-hook 1
• Database Link:
  NP_665906
  Entrez Gene 15361 MouseEntrez Gene 117062 RatEntrez Gene 3159 Human
  UniProt ID P17096
• Background: This gene encodes a non-histone protein involved in many cellular processes; including regulation of inducible gene transcription; integration of retroviruses into chromosomes; and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of A+T-rich regions in double-stranded DNA. It has little secondary structure in solution but assumes distinct conformations when bound to substrates such as DNA or other proteins. The encoded protein is frequently acetylated and is found in the nucleus. At least seven transcript variants encoding two different isoforms have been found for this gene.
• Synonyms: HMG-R; HMGA1A; HMGIY

Reference Data

• Protein Families: Druggable Genome, Stem cell - Pluripotency, Stem cell relevant signaling - JAK/STAT signaling pathway, Transcription Factors