NPPC Rabbit Polyclonal Antibody

CAT#: TA322184

Anti-NPPC Rabbit Polyclonal Antibody

Product Images

Immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using TA322184 (NPPC Antibody) at dilution 1/70 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using TA322184 (NPPC Antibody) at dilution 1/70, treated with synthetic peptide. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 50-200
  Positive control: Human gasrtic cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 111-125 amino acids of Human notch 4
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: natriuretic peptide C
• Database Link:
  NP_077720
  Entrez Gene 18159 MouseEntrez Gene 114593 RatEntrez Gene 4880 Human
  UniProt ID P23582
• Background: This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats; and an intracellular domain consisting of multiple; different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia; notch interaction with its cell-bound ligands (delta; serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human; but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network; and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands; and may play a role in vascular; renal and hepatic development. This gene may be associated with susceptibility to schizophrenia in a small portion of cases. An alternative splice variant has been described but its biological nature has not been determined.
• Synonyms: CNP; CNP2

Reference Data

• Protein Families: Secreted Protein