SLC22A17 Rabbit Polyclonal Antibody

CAT#: TA322260

Anti-SLC22A17 Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 25-100
  Positive control: Human brain
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 511-524 amino acids of human solute carrier family 22, member 17
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: solute carrier family 22 member 17
• Database Link:
  NP_057693
  Entrez Gene 59049 MouseEntrez Gene 305886 RatEntrez Gene 51310 Human
  UniProt ID Q8WUG5
• Background: Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3); followed by internalization of holo-24p3 and release of iron; thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3); followed by internalization of apo-24p3 and its association with an intracellular siderophore; leading to iron chelation and iron transfer to the extracellular medium; thereby reducing intracellular iron concentration and resulting in apoptosis.
• Synonyms: 24p3R; BOCT; BOIT; hBOIT; NGALR; NGALR2; NGALR3

Reference Data

• Protein Families: Druggable Genome, Transmembrane