SLC22A17 Rabbit Polyclonal Antibody

CAT#: TA322261

Anti-SLC22A17 Rabbit Polyclonal Antibody


USD 345.00

In Stock*

Size
    • 100 ul

Other products for "SLC22A17"

Specifications

Product Data
Applications IHC, WB
Recommended Dilution WB: 500-2000
WB positive control: Human esophagus cancer tissue
IHC: 25-100
Positive control: Human esophagus cancer
Predicted cell location: Cytoplasm
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Synthetic peptide corresponding to a region derived from 511-524 amino acids of human solute carrier family 22, member 17
Formulation PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration lot specific
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 56 kDa
Gene Name solute carrier family 22 member 17
Background Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3); followed by internalization of holo-24p3 and release of iron; thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3); followed by internalization of apo-24p3 and its association with an intracellular siderophore; leading to iron chelation and iron transfer to the extracellular medium; thereby reducing intracellular iron concentration and resulting in apoptosis.
Synonyms 24p3R; BOCT; BOIT; hBOIT; NGALR; NGALR2; NGALR3
Reference Data
Protein Families Druggable Genome, Transmembrane

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