SELS (SELENOS) Rabbit Polyclonal Antibody

CAT#: TA322292

Anti-VIMP Rabbit Polyclonal Antibody

Product Images

Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using TA322292 (SELENOS Antibody) at dilution 1/40 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using TA322292 (SELENOS Antibody) at dilution 1/40, treated with synthetic peptide. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 50-200
  Positive control: Human thyroid cancer
  Predicted cell location: Cytoplasm, Endoplasmic reticulum membrane
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 98-112 amino acids of human VCP-interacting membrane protein
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: VCP interacting membrane selenoprotein
• Database Link:
  NP_060915
  Entrez Gene 109815 MouseEntrez Gene 286900 RatEntrez Gene 55829 Human
  UniProt ID Q9BQE4
• Background: This gene encodes a selenoprotein; which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure; the sec insertion sequence (SECIS); that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Studies suggest that this protein may regulate cytokine production; and thus play a key role in the control of the inflammatory response. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
• Synonyms: AD-015; ADO15; SBBI8; SELS; SEPS1

Reference Data

• Protein Families: Druggable Genome