VGLL1 Rabbit Polyclonal Antibody

CAT#: TA322329

Anti-VGLL1 Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 2000-10000
  WB positive control: 293T cells
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 62-75 amino acids of human vestigial like 1 (Drosophila)
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 29 kDa
• Gene Name: vestigial like family member 1
• Database Link:
  NP_057351
  Entrez Gene 170828 MouseEntrez Gene 363508 RatEntrez Gene 51442 Human
  UniProt ID Q99990
• Background: The protein encoded by this gene binds proteins of the TEA domain family of transcription factors (TEFs) through the Vg (vestigial) homology region found in its N-terminus. It may thus function as a specific coactivator for the mammalian TEFs. TDU interacted directly with the TEA domain family member; TEF1; and deletion of the Vg homology region abolished the interaction. The TDU-TEF1 dimer activated a reporter plasmid; and expression of TDU in Drosophila rescued loss of Vg function. The interaction was stronger in cardiac myocytes; suggesting a myocyte-specific factor may participate in the interaction. Vgll1 was weakly active in driving expression of a reporter gene from the mouse skeletal muscle alpha-actin promoter; and Vgll1 could partially reverse the inhibitory effect of TEF1 in this assay.
• Synonyms: TDU; VGL1

Reference Data

• Protein Families: Transcription Factors