HDAC4 Rabbit Polyclonal Antibody

CAT#: TA322535

Anti-HDAC4 Rabbit Polyclonal Antibody

Product Images

Immunohistochemistry of paraffin-embedded Human tonsil tissue using TA322535 (HDAC4 Antibody) at dilution 1/15 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human tonsil tissue using TA322535 (HDAC4 Antibody) at dilution 1/15, treated with synthetic peptide. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 10-50
  Positive control: Human tonsil
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 536-548 amino acids of Human histone deacetylase 4
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: histone deacetylase 4
• Database Link:
  NP_006028
  Entrez Gene 208727 MouseEntrez Gene 363287 RatEntrez Gene 9759 Human
  UniProt ID P56524
• Background: Histones play a critical role in transcriptional regulation; cell cycle progression; and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly; but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.
• Synonyms: AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A; HDACA

Reference Data

• Protein Families: Druggable Genome, Transcription Factors