CDK7 Rabbit Polyclonal Antibody

CAT#: TA323115

Anti-CDK7 Rabbit Polyclonal Antibody

Product Images

Gel: 10%SDS-PAGE Lysate: 60 μg Lane: A549 cells Primary antibody: TA323115 (CDK7 Antibody) at dilution 1/500 Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 2 minutes

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  Immunohistochemistry of paraffin-embedded Human lung cancer tissue using TA323115 (CDK7 Antibody) at dilution 1/30 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human lung cancer tissue using TA323115 (CDK7 Antibody) at dilution 1/30, treated with fusion protein. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 500-2000
  WB positive control: A549 cells
  IHC: 15-50
  Positive control: Human lung cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to a region derived from 12-295 amino acids of human
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 39 kDa
• Gene Name: cyclin-dependent kinase 7
• Database Link:
  NP_001790
  Entrez Gene 12572 MouseEntrez Gene 171150 RatEntrez Gene 1022 Human
  UniProt ID P50613
• Background: The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28; and Schizosaccharomyces pombe cdc2; and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1; which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH; that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle.
• Synonyms: CAK1; CDKN7; HCAK; MO15; p39MO15; STK1

Reference Data

• Protein Families: Druggable Genome, Protein Kinase, Stem cell - Pluripotency, Transcription Factors
• Protein Pathways: Cell cycle, Nucleotide excision repair