FAIM1 (FAIM) Rabbit Polyclonal Antibody

CAT#: TA323397

Anti-FAIM Rabbit Polyclonal Antibody

Product Images

Predicted band size: 20 kDa. Positive control: 293 cell lysate. Recommended dilution: 1/500-2000. (Gel: 12%SDS-PAGE Lysate: 40 ug Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute)

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-2000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Full length fusion protein
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 20 kDa
• Gene Name: Fas apoptotic inhibitory molecule
• Database Link:
  NP_001028202
  Entrez Gene 23873 MouseEntrez Gene 140930 RatEntrez Gene 55179 Human
  UniProt ID Q9NVQ4
• Background: FAIM (Fas apoptosis inhibitory molecule) was identified as a protein that was inducibly expressed in B lymphocytes resistant to Fas-mediated apoptosis. Expression of FAIM inhibits receptor-mediated apoptosis in B cells as well as other cell types. FAIM is expressed in germinal center B cells, is positively regulated by IRF-4, and is also capable of inducing IRF-4 expression in a feed-forward mechanism. FAIM also regulates T cell receptor-mediated apoptosis by modulating Akt activation and Nur77 expression. Knockout mice for FAIM show an increased sensitivity to Fas-mediated apoptosis within B and T cells as well as hepatocytes. An alternatively spliced form of FAIM, termed FAIM-L, is found predominantly in the brain. In the nervous system, the originally identified FAIM does not appear to play a role in apoptosis, but rather can promote neurite outgrowth through the activation of Erk and NF-?B pathways. In contrast, FAIM-L does inhibit neuronal cell death triggered by death receptors.
• Synonyms: FAIM1