Zyxin (ZYX) Rabbit Polyclonal Antibody

CAT#: TA323459

Anti-ZYX Rabbit Polyclonal Antibody

Product Images

Predicted band size: 80 kDa. Positive control: HeLa cell lysate. Recommended dilution: 1/500-2000. (Gel: 8%SDS-PAGE Lysate: 40 ug Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute)

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-2000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to N terminal 300 amino acids of human zyxin
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 80 kDa
• Gene Name: zyxin
• Database Link:
  NP_001010972
  Entrez Gene 22793 MouseEntrez Gene 114636 RatEntrez Gene 7791 Human
  UniProt ID Q15942
• Background: The zyxin family of proteins includes LIMD1, ajuba, trip6 and zyxin, each of which contains three LIM domains at the carboxy-terminus. Zyxin family members associate with the actin cytoskeleton and are components of both the cell-cell junction adhesive complex and the integrin-mediated adhesive complex. They shuttle in and out of the nucleus where they may function in transcriptional activation.Zyxin is involved in the regulation of mechanical force-induced actin polymerization at focal adhesions, and in regulation of adhesion and migration, possibly through recruitment of Ena/VASP proteins to focal adhesions. Zyxin interacts with and may regulate the function of the tumor suppressor myopodin, which inhibits tumor growth and metastasis.
• Synonyms: ESP-2; HED-2

Reference Data

• Protein Pathways: Focal adhesion