Apolipoprotein B (APOB) Rabbit Polyclonal Antibody

CAT#: TA323677

Anti-APOB Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 15-50
  Positive control: Human colon cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 2158-2177 amino acids of human apolipoprotein B (including Ag(x) antigen)
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: apolipoprotein B
• Database Link:
  NP_000375
  Entrez Gene 54225 RatEntrez Gene 238055 MouseEntrez Gene 338 Human
  UniProt ID P04114
• Background: This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms; apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single; very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA); resulting in the creation of a stop codon; and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia; normotriglyceridemic hypobetalipoproteinemia; and hypercholesterolemia due to ligand-defective apoB; diseases affecting plasma cholesterol and apoB levels.
• Synonyms: FLDB; LDLCQ4

Reference Data

• Protein Families: Druggable Genome, Transmembrane