beta 2 Adrenergic Receptor (ADRB2) Rabbit Polyclonal Antibody

CAT#: TA323757

Anti-ADRB2 Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 200-1000
  WB positive control: Human liver cancer tissue
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide peptide corresponding to a region derived from 21-33 amino acids of human adrenoceptor beta 2, surface
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 46 kDa
• Gene Name: adrenoceptor beta 2
• Database Link:
  NP_000015
  Entrez Gene 11555 MouseEntrez Gene 24176 RatEntrez Gene 154 Human
  UniProt ID P07550
• Background: This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors; the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein; an adenylyl cyclase; cAMP-dependent kinase; and the counterbalancing phosphatase; PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms; point mutations; and/or downregulation of this gene are associated with nocturnal asthma; obesity and type 2 diabetes.?
• Synonyms: ADRB2R; ADRBR; B2AR; BAR; BETA2AR

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Calcium signaling pathway, Endocytosis, Neuroactive ligand-receptor interaction