CARD8 Rabbit Polyclonal Antibody

CAT#: TA324044

Anti-CARD8 Rabbit Polyclonal Antibody

Product Images

Predicted band size: 49 kDa. Positive control: K562 and Hela cell lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lane 1.K562 cell lysate Lane 2.Hela cell lysate Lysates: 30 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute)

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-2000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to N terminal 200 amino acids of human Caspase recruitment domain-containing protein 8
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 49 kDa
• Gene Name: caspase recruitment domain family member 8
• Database Link:
  NP_001171829
  Entrez Gene 22900 Human
  UniProt ID Q9Y2G2
• Background: The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene, but their biological validity has not been determined.
• Synonyms: CARDINAL; DACAR; DAKAR; NDPP; NDPP1; TUCAN

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: NOD-like receptor signaling pathway