Hsp47 (SERPINH1) Mouse Monoclonal Antibody [Clone ID: 1C4-1A6]

CAT#: TA326347

Mouse monoclonal Hsp47 Antibody

Product Images

Western blot of A431 lysates showing the detection of ~47 kDa Hsp47 protein using Anti-Hsp47 antibody [1C4-1A6] (TA326347).Lane 1: MW ladder. Lane 2: Anti-Hsp47 (1:250). Lane 3: Anti-Hsp47 (1:500). Lane 4: Anti-Hsp47 (1:1000). Load: 20 µ A431 per lane. Bl

Specifications

Product Data

• Clone Name: 1C4-1A6
• Applications: WB
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1, kappa
• Clonality: Monoclonal
• Immunogen: Human Hsp47, full length
• Formulation: PBS pH7.4, 50% glyercol and 0.09% sodium azide
• Concentration: lot specific
• Purification: Protein G Purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: serpin family H member 1
• Database Link:
  NP_001226
  Entrez Gene 871 Human
  UniProt ID P50454
• Background: Versican (chondroitin sulfate proteoglycan 2) is a large extracellular matrix proteoglycan involved in cell growth and differentiation. Important as a structural molecule, versican creates loose and hydrated matrices during key events in development and disease. The protein contains hyaluronic acid and glycosminoglycan-binding domains, epidermal growth factor-like repeats, a Lectinlike sequence and a complement regulatory protein-like domain. Splice variants differ greatly in length and degree of modification by glycoaminoglycan chains. Accumulation around smooth muscle cells in lesions of athero-sclerosis suggests a role for versican in atherogenesis. Versican, differentially expressed in human melanoma, plays a role in tumor development and may be a reliable marker for clinical diagnosis. The organization of HA- and versican-rich pericellular matrices may faciliatate migration and mitosis by diminishing cell surface adhesivity and affecting cell shape through steric exclusion and the viscous properties of HA proteoglycan gels.
• Synonyms: AsTP3; CBP1; CBP2; gp46; HSP47; OI10; PIG14; PPROM; RA-A47; SERPINH2
• Note: Detects a 47kDa protein

Reference Data

• Protein Families: Druggable Genome