CENPA Mouse Monoclonal Antibody [Clone ID: 5A7-2E11]
Other products for "CENPA"
Specifications
Product Data | |
Clone Name | 5A7-2E11 |
Applications | WB |
Recommended Dilution | WB: 1:1000 |
Reactivities | Human. Other species not yet tested |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Synthetic peptide corresponding to a portion of human CENP-A. |
Formulation | PBS, 50% glycerol |
Concentration | lot specific |
Purification | Protein G Purified |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Gene Name | centromere protein A |
Database Link | |
Background | A replicated chromosome includes two kinetochores that control chromosome segregation during mitosis. The Centromere Protein-A, CENP-A, is a Histone H3-like protein that contains a C-terminal H3-like domain, which is required for centromere localization of CENP-A, and an antigenic N-terminal domain.CENP-A, originally isolated from HeLa cells, is essential for kinetochore targeting of CENP-C. In the presence of DNA CENP-A forms an octa-meric complex with histones H4, H2A, H2B. CENP-A specifically localizes to active centromeres and is a component of specializedcentromeric nucleosomes, on which kinetochores are assembled. CENP-A is essential for nucleosomal packaging of centromeric DNA at interphase and functions as a centromere formation marker on the chromosome. |
Synonyms | CenH3; CENP-A |
Note | Detects ~18kDa. Recognizes Human CENP-A |
Reference Data |
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