TNFRSF1A Rabbit Polyclonal Antibody

CAT#: TA326458

Rabbit Polyclonal Anti-TNF-R1 Antibody

Specifications

Product Data

• Recommended Dilution: WB: 1:1000
• Reactivities: Bovine, Canine, Human, Monkey, Mouse, Rabbit, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Peptide corresponding to AA 20-43 of the mouse TNF-R1 sequence, identical to rat and human over those residues
• Formulation: PBS pH 7.4; 50% glycerol, 0.09% azide.
• Concentration: lot specific
• Purification: Peptide Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: tumor necrosis factor receptor superfamily member 1A
• Database Link:
  NP_001056
  Entrez Gene 21937 MouseEntrez Gene 25625 RatEntrez Gene 722033 MonkeyEntrez Gene 7132 Human
  UniProt ID P19438
• Background: The Tumor Necrosis Factor Receptor (TNFR) also known as Cluster of differentiation (CD120) is a protein that belongs to the (TNF)/ (TNFR) superfamily. TNF interacts with two distinct receptors TNFR1 and TNFR2. These receptors share no homology on their cytoplasmic sequences.TNFR1 also known as p55/p60 is a high affinity receptor for TNF-. The TNFR1 has an extracellular domain with variable numbers of cysteine-rich repeats. The functional properties of TNFR1 are targets in new therapies for osteoporosis, chronic inflammatory and autoimmune diseases . The TNF-/TNFR1 receptor complex is responsible for the recruitment and the subsequent activation of the caspase (aspartate-specific cysteine proteases) that regulate apoptosis.
• Synonyms: CD120a; FPF; MS5; p55; p55-R; p60; TBP1; TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55
• Note: Identifies a band ~55kD on WB

Reference Data

• Protein Families: Druggable Genome, Secreted Protein, Transcription Factors, Transmembrane
• Protein Pathways: Adipocytokine signaling pathway, Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, Cytokine-cytokine receptor interaction, MAPK signaling pathway