IL36 gamma (IL36G) Rabbit Polyclonal Antibody

CAT#: TA326667

Rabbit Polyclonal IL-36G Antibody

Product Images

Western blot analysis of IL-36G in human spleen tissue lysate with IL-36G antibody at (A) 1 and (B) 2 ug/ml.

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  Immunohistochemistry of IL-36G in human bladder tissue with IL-36G antibody at 5 ug/mL.

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  Immunofluorescence of IL-36G in human bladder tissue with IL-36G antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: IL-36G antibody was raised against a 13 amino acid peptide near the carboxy terminus of human IL-36G.
• Formulation: IL-36G antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: IL-36G antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 19 kDa; Observed: 22 kDa
• Gene Name: interleukin 36, gamma
• Database Link:
  NP_062564
  Entrez Gene 56300 Human
  UniProt ID Q9NZH8
• Background: IL-36G is is a member of the interleukin 1 cytokine family whose gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2 (1). IL-36G is thought to activate the NF-kappaB pathway through IL-1 receptor family members IL-1RL2 and IL-1RAcP (2). Like the related proteins IL-36A and IL-36B, IL-36G requires post-translational processing for full agonist activity, but the cleavage mechanism is currently unknown (3). IL-36G expression is stimulated by interferon-gamma, tumor necrosis factor-alpha and interleukin 1 (4). The IL-36 cytokines have been suggested to amplify Th1 responses by enhancing proliferation and Th1 polarization of naive CD4+ T cells (5).
• Synonyms: IL-1F9; IL-1H1; IL-1RP2; IL1E; IL1F9; IL1H1; IL1RP2

Reference Data

• Protein Families: Druggable Genome, Secreted Protein