ATF6 Rabbit Polyclonal Antibody

CAT#: TA326767

ATF6 Rabbit Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using ATF6 antibody.

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  Immunohistochemistry of paraffin-embedded human esophagus using ATF6 antibody.

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  Immunohistochemistry of paraffin-embedded rat brain using ATF6 antibody.

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  Immunohistochemistry of paraffin-embedded rat lung using ATF6 antibody at dilution of 1:200 (200x lens).

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  Immunohistochemistry of paraffin-embedded rat spleen using ATF6 antibody at dilution of 1:200 (200x lens).

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  Immunofluorescence analysis of A549 cell using ATF6 antibody. Blue: DAPI for nuclear staining

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Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB 1:500 - 1:2000;IHC 1:50 - 1:100IF 1:50 - 1:200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: C term -peptide of human ATF6
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 75 kDa
• Gene Name: activating transcription factor 6
• Database Link:
  NP_031374
  Entrez Gene 226641 MouseEntrez Gene 304962 RatEntrez Gene 22926 Human
  UniProt ID P18850
• Background: This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011]
• Synonyms: ACHM7; ATF6A

Reference Data

• Protein Families: Transcription Factors
• Protein Pathways: Alzheimer's disease