PPAR gamma (PPARG) Rabbit Polyclonal Antibody

CAT#: TA326810

PPARG Rabbit Polyclonal Antibody

Product Images

Immunohistochemistry of paraffin-embedded H-ovary using PPARG Antibody at Dilution 1:100

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  Immunofluorescence analysis of A549 cell using PPARG antibody. Blue: DAPI for nuclear staining.

Specifications

Product Data

• Applications: ICC/IF, IHC
• Recommended Dilution: IHC 1:50 - 1:100;IF 1:50 - 1:100
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: N term -peptide of human PPARG
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: peroxisome proliferator activated receptor gamma
• Database Link:
  NP_005028
  Entrez Gene 19016 MouseEntrez Gene 25664 RatEntrez Gene 5468 Human
  UniProt ID P37231
• Background: Peroxisome proliferator-activated receptor ? (PPAR?) is a member of the ligand-activated nuclear receptor superfamily and functions as a transcriptional activator (1). PPAR? is preferentially expressed in adipocytes as well as in vascular smooth muscle cells and macrophage (2). Besides its role in mediating adipogenesis and lipid metabolism (2), PPAR? also modulates insulin sensitivity, cell proliferation and inflammation (3). PPAR? transcriptional activity is inhibited by MAP kinase phosphorylation of PPAR? at Ser84 (4,5).1. Tontonoz, P. et al. (1995) Curr. Opin. Genet. Dev. 5, 571-576.2. Rosen, E.D. et al. (1999) Mol. Cell 4, 611-617.3. Murphy, G.J. and Holder, J.C. (2000) Trends Pharmacol. Sci. 21, 469-474.4. Camp, H.S. and Tafuri, S.R. (1997) J. Biol. Chem. 272, 10811-10816.5. Adams, M. et al. (1997) J. Biol. Chem. 272, 5128-5132.
• Synonyms: CIMT1; GLM1; NR1C3; PPARG1; PPARG2; PPARgamma

Reference Data

• Protein Families: Druggable Genome, Nuclear Hormone Receptor, Transcription Factors
• Protein Pathways: Huntington's disease, Pathways in cancer, PPAR signaling pathway, Thyroid cancer