STAR Rabbit Polyclonal Antibody

CAT#: TA326898

STAR Rabbit Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using STAR antibody.

Specifications

Product Data

• Applications: IP, WB
• Recommended Dilution: WB 1:500 - 1:2000
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human STAR
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 32 kDa
• Gene Name: steroidogenic acute regulatory protein
• Database Link:
  NP_000340
  Entrez Gene 20845 MouseEntrez Gene 6770 Human
  UniProt ID P49675
• Background: Steroidogenic acute regulatory protein (StAR) plays a significant role in cholesterol transport from the cytoplasmic outer membrane to the inner mitochondrial membrane . The 37 kDa precursor is cleaved to generate an active 28 kDa protein capable of facilitating cholesterol metabolism into pregnenolone . StAR is prevalently expressed in mitochondria of steroid-producing adrenal and gonadal tissue . Abnormalities in StAR gene expression are impacted in autosomal Lipoid Congenial Adrenal Hyperplasia (LCAH) resulting in defects in pregnenolone and cortisol synthesis . The mechanism of cholesterol binding to StAR has yet to be elucidated .
• Synonyms: STARD1

Reference Data

• Protein Families: Druggable Genome