TDP43 (TARDBP) Rabbit Polyclonal Antibody

CAT#: TA326978

Rabbit anti-TARDBP Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using TARDBP antibody.

Specifications

Product Data

• Applications: IP, WB
• Recommended Dilution: WB 1:500 - 1:2000;IP 1:20 - 1:50
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human TARDBP
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 43 kDa
• Gene Name: TAR DNA binding protein
• Database Link:
  NP_031401
  Entrez Gene 230908 MouseEntrez Gene 298648 RatEntrez Gene 23435 Human
  UniProt ID Q13148
• Background: TDP43 (TAR DNA-binding protein 43) is involved in transcriptional regulation and exon splicing. While normal TDP43 is a nuclear protein, pathological TDP43 is a component of insoluble aggregates in patients with frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). In these disorders, TDP43 is abnormally ubiquitinated, phosphorylated and cleaved to generate carboxy-terminal fragments that are sequestered as insoluble aggregates in neuronal nuclei, perikarya, and neurites. Additionally, TDP43 inhibits the expression of the HIV-1 gene and regulates CFTR gene splicing.
• Synonyms: ALS10; TDP-43

Reference Data

• Protein Families: Transcription Factors