Galectin 3 (LGALS3) Rabbit Polyclonal Antibody

CAT#: TA327051

Rabbit anti-LGALS3 Polyclonal Antibody

Product Images

Immunofluorescence analysis of MCF-7 cells using Galectin 3/Galectin 3/LGALS3 antibody (TA327051). Blue: DAPI for nuclear staining.

Specifications

Product Data

• Applications: ICC/IF, WB
• Recommended Dilution: WB 1:500 - 1:2000;IF 1:50- 1:200
• Reactivities: Human, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human LGALS3
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: lectin, galactoside binding soluble 3
• Database Link:
  NP_002297
  Entrez Gene 83781 RatEntrez Gene 3958 Human
  UniProt ID P17931
• Background: Galectins are a family of soluble b-galactoside-binding animal lectins that modulate cell-to-cell adhesion and cell-to-extracellular matrix (ECM) inter- actions and play a role in tumor progression, pre-mRNA splicing and apop-tosis. The galectin-3 protein, also known as Mac-2, hMac-2, GALBP, CBP35 or LGALS3, contains a single carbohydrate binding domain, which binds galactose-containing glycoconjugates. Galectin-3 is expressed in colonic and intestinal epithelium, inflammatory macrophages, papillary and follicular carcinomas, neoplastic astrocytes and some B and T lymphocytes. Upregulated expression of galectin-3 is involved in cancer progression and metastasis. Galectin-3 mediates the endocytosisof ?1 Integrins in a lactose-dependent manner and is associated with thyroid malignancy and Crohn’s diseasedisease. It may also be used as a marker for diagnosing cases involving Hurthle cell adenomas and carcinomas.
• Synonyms: CBP35; GAL3; GALBP; GALIG; L31; LGALS2; MAC2

Reference Data

• Protein Families: Secreted Protein