NQO1 Rabbit Polyclonal Antibody

CAT#: TA327061

Rabbit anti-NQO1 Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using NQO1 antibody.

Specifications

Product Data

• Applications: ICC/IF, WB
• Recommended Dilution: WB 1:500 - 1:2000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthetic peptide of human NQO1
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 31 kDa
• Gene Name: NAD(P)H quinone dehydrogenase 1
• Database Link:
  NP_000894
  Entrez Gene 18104 MouseEntrez Gene 24314 RatEntrez Gene 1728 Human
  UniProt ID P15559
• Background: NAD(P)H:quinone oxidoreductase 1 (NQO1) is a flavoprotein that catalyzes the two-electron reduction of quinones and their derivatives. This enzyme protects cells against redox cycling and oxidative stress . The expression of NQO1 is increased in liver, colon and breast tumors and non-small cell lung cancer (NSCLC) compared with the normal tissues. Moreover, expression levels are also elevated in developing tumors, suggesting a role for NQ01 in the prevention of tumor development. Studies on NQO1 knockout mice suggest that the lack of NQO1 enzymatic activity changes intracellular redox states resulting in a reduction in apoptosis, which in turns leads to myeloid hyperplasia of bone marrow.
• Synonyms: DHQU; DIA4; DTD; NMOR1; NMORI; QR1

Reference Data

• Protein Families: Druggable Genome