Frataxin (FXN) Rabbit Polyclonal Antibody

CAT#: TA327162

Rabbit anti-FXN Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using FXN antibody.

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  Immunohistochemistry of paraffin-embedded human liver cancer using FXN antibody at dilution of 1:100 (200x lens).

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  Immunohistochemistry of paraffin-embedded rat kidney using FXN antibody at dilution of 1:100 (200x lens).

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  Immunofluorescence analysis of MCF7 cell using FXN antibody. Blue: DAPI for nuclear staining.

Specifications

Product Data

• Applications: ICC/IF, IHC, WB
• Recommended Dilution: WB 1:500 - 1:2000;IHC 1:50- 1:200;IF 1:50- 1:200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human FXN
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: frataxin
• Database Link:
  NP_000135
  Entrez Gene 14297 MouseEntrez Gene 499335 RatEntrez Gene 2395 Human
  UniProt ID Q16595
• Background: FXN, also named as FRDA, X25, m81-FXN, d-FXN, m78-FXN and i-FXN, belongs to the frataxin family. It promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe2+ to proteins involved in these pathways. FXN may play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe2+ to Fe3+; the oligomeric form but not the monomeric form has in vitro ferroxidase activity. FXN is cleaved to be 4 chains. The mature form of FXN is 14kd or 18kd.
• Synonyms: CyaY; FA; FARR; FRDA; X25

Reference Data

• Protein Families: Druggable Genome