Fascin (FSCN1) Mouse Monoclonal Antibody [Clone ID: 55-k2]

CAT#: TA327676

Mouse Monoclonal Fascin Antibody

Product Images

Immunohistochemistry staining of Paraffin Hodgkin lymphoma tissue by Fascin antibody (dilution: 1:100 - 1:500; visualization of staining: Cytoplasmic)

Specifications

Product Data

• Clone Name: 55-k2
• Applications: IHC
• Recommended Dilution: IHC: 1:100 - 1:500
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Formulation: This antibody is supplied as cell culture supernatant diluted in tris buffered saline, pH 7.3-7.7, with 1% BSA and <0.1% sodium azide.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: fascin actin-bundling protein 1
• Database Link:
  NP_003079
  Entrez Gene 6624 Human
  UniProt ID Q16658
• Synonyms: FAN1; HSN; p55; SNL
• Note: Anti-fascin is a very sensitive marker for Reed-Sternberg cells and variants in nodular sclerosis, mixed cellularity, and lymphocyte depletion Hodgkin disease. It is uniformly negative in lymphoid cells, plasma cells, and myeloid cells. Anti-fascin is positive in dendritic cells. This marker may be helpful to distinguish between Hodgkin lymphoma and non-Hodgkin lymphoma in difficult cases. Also, the lack of expression of fascin in the neoplastic follicles in follicular lymphoma can be helpful in distinguishing these lymphomas from reactive follicular hyperplasia in which the number of follicular dendritic cells is normal or increased. Anti-fascin has been suggested as a prognostic marker in neuroendocrine neoplasms of the lung as well as in ovarian cancer.