TBX21 Rabbit Monoclonal Antibody [Clone ID: MRQ-46]

CAT#: TA327741

Rabbit Monoclonal T-bet Antibody

Product Images

Immunohistochemistry staining of Paraffin Tonsil tissue by T-bet antibody (dilution: 1:100 - 1:500; visualization of staining: Nuclear)

Specifications

Product Data

• Clone Name: MRQ-46
• Applications: IHC
• Recommended Dilution: IHC: 1:100 - 1:500
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG1
• Clonality: Monoclonal
• Formulation: The antibody is diluted in tris buffered saline, pH 7.3-7.7, with 1% BSA and <1% sodium azide.
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: T-box 21
• Database Link:
  NP_037483
  Entrez Gene 30009 Human
  UniProt ID Q9UL17
• Synonyms: T-bet; T-PET; TBET; TBLYM
• Note: T-bet, a T-box transcription factor, is expressed in CD4+ T-lymphocytes committed to T-helper (Th)1 T-cell development from naïve T-helper precursor cells (Thp) and redirects Th2 T cells to Th1 development.Anti-T-bet is a marker of mature T-cells and is expressed at very low levels in Th cells and is absent in precursor T-lymphoblastic leukemia/lymphoma cells. Scattered small lymphocytes in the interfollicular T-cell zone of lymphoid tissue, including tonsil, lymph node, and spleen exhibit nuclear staining for T-bet, with no T-bet staining being observed in germinal centers, mantle or marginal zones.T-bet is expressed in a significant subset of B-cell lymphoproliferative disorders, particularly at an early stage of B-cell development (precursor B-cell lymphoblastic leukemia/lymphoblastic lymphoma), and B-cell neoplasms derived from mature B cells, including CLL/SLL, marginal zone lymphoma, and hairy cell leukemia. In contrast, B-cell neoplasms derived from pregerminal center or germinal center B-cells, including mantle cell lymphoma, follicular lymphoma, diffuse large B-cell lymphoma, and Burkitt lymphoma are negative for T-bet. Anti-T-bet is a useful marker for the diagnosis and subtyping of B-cell and T-cell lymphoproliferative disorders. T-bet is not expressed in precursor T-cell lymphoblastic lymphoma/leukemia.

Reference Data

• Protein Families: Druggable Genome, Transcription Factors