MSH2 Mouse Monoclonal Antibody [Clone ID: 1184CT1.3.2]

CAT#: TA328162

Mouse monoclonal anti-MSH2 antibody (Center)


USD 450.00

5 Days*

Size
    • 400 ul

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Specifications

Product Data
Clone Name 1184CT1.3.2
Applications WB
Recommended Dilution WB: 1:2000
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Purified His-tagged MSH2 protein was used to produced this monoclonal antibody.
Formulation PBS with 0.09% (W/V) sodium azide
Concentration lot specific
Purification This antibody is purified through a protein G column, followed by dialysis against PBS.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name mutS homolog 2
Background Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis.
Synonyms COCA1; FCC1; HNPCC; HNPCC1; LCFS2
Reference Data
Protein Families Druggable Genome, Stem cell - Pluripotency
Protein Pathways Colorectal cancer, Mismatch repair, Pathways in cancer

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.