Kcnk10 Rabbit Polyclonal Antibody

CAT#: TA328954

Rabbit polyclonal Anti-K2P10.1 (TREK-2)

Product Images

Western blot analysis of rat cerebellum lysate: 1. Anti-K2P10.1 (TREK-2) antibody, (1:200). 2. Anti-K2P10.1 (TREK-2) antibody, preincubated with the control peptide antigen.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:200-1:2000; IHC: 1:100-1:3000
• Reactivities: Human, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Peptide TFRNYSLDEEKKEDETEKMC, corresponding to amino acid residues 475-494 of rat K2P10.1 . Intracellular, C-terminal domain.
• Formulation: Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.025% NaN3.
• Purification: Affinity purified on immobilized antigen.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: potassium two pore domain channel subfamily K member 10
• Database Link:
  NP_075584
  Entrez Gene 54207 HumanEntrez Gene 65272 Rat
  UniProt ID Q9JIS4
• Background: K2P10.1 is a member of the 2-pore (2P) domain K+ channels. These K+ channels also also known as background or “leak” channels and help to set the resting membrane potential. K2P channels can be activated by a wide variety of stimuli including temperature, pH, mechanical stretch, inhalation anesthetics, etc. The channels can also be subclassified based on their specific activators. K2P10.1 can be integrated to a K2P subfamily which includes K2P2.1 (TREK1) and K2P4.1 (TRAAK) that are activated by intracellular unsaturated fatty acids such as arachidonic acid, low intracellular pH and mechanical stretch. K2P10.1 mRNA expression has been detected in the brain (primarily in the cerebellum) and in peripheral tissues such as pancreas and kidney.
• Synonyms: FLJ43399; K2p10.1; TREK-2; TREK2