TBXAS1 Rabbit Polyclonal Antibody

CAT#: TA332490

Rabbit anti-TBXAS1 Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using TBXAS1 antibody.

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  Immunohistochemistry of paraffin-embedded human endometrial cancer using TBXAS1 antibody at dilution of 1:200 (400x lens).

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  Immunohistochemistry of paraffin-embedded human thyroid cancer using TBXAS1 antibody at dilution of 1:200 (400x lens).

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  Immunohistochemistry of paraffin-embedded mouse lung using TBXAS1 antibody at dilution of 1:200 (400x lens).

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB 1:500 - 1:2000;IHC 1:50- 1:200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human TBXAS1
• Formulation: Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: thromboxane A synthase 1
• Database Link:
  NP_001052
  Entrez Gene 21391 MouseEntrez Gene 24886 RatEntrez Gene 6916 Human
  UniProt ID P24557
• Background: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Synonyms: BDPLT14; CYP5; CYP5A1; GHOSAL; THAS; TS; TXAS; TXS

Reference Data

• Protein Families: Druggable Genome, P450
• Protein Pathways: Arachidonic acid metabolism, Metabolic pathways