HLAA (HLA-A) Rabbit Polyclonal Antibody

CAT#: TA332507

Rabbit anti-HLA-A Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using HLA-A antibody.

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  Immunohistochemistry of paraffin-embedded human endometrial cancer using HLA-A antibody at dilution of 1:500 (200x lens).

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  Immunohistochemistry of paraffin-embedded human neurilemmoma using HLA-A antibody at dilution of 1:500 (200x lens).

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  Immunohistochemistry of paraffin-embedded mouse kidney using HLA-A antibody at dilution of 1:500 (200x lens).

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  Immunohistochemistry of paraffin-embedded mouse liver using HLA-A antibody at dilution of 1:500 (200x lens).

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Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB 1:500 - 1:2000;IHC 1:50- 1:200
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human HLA-A
• Formulation: Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 365
• Gene Name: major histocompatibility complex, class I, A
• Database Link:
  NP_002107
  Entrez Gene 3105 Human
  UniProt ID P04439
• Background: Human major histocompatibility complex (MHC) antigens, also referred to as human leukocyte antigens (HLA), are encoded by genes located on the short arm of chromosome 6 (6p21.3). There are two classes of HLA antigens: class I (HLA-A, B and C) and class II (HLA-D). This class I molecules are polymorphic membrane glycoproteins composed of a heavy (alpha) chain (44 kDa) which is encoded by a HLA class I gene (HLA-A, B or C), and β2-microglobulin light (beta) chain (12 kDa). They are involved in the presentation of foreign antigens to the immune system. (PMID: 667938; 3375250)
• Synonyms: HLAA

Reference Data

• Protein Families: Transmembrane
• Protein Pathways: Allograft rejection, Antigen processing and presentation, Autoimmune thyroid disease, Cell adhesion molecules (CAMs), Endocytosis, Graft-versus-host disease, Natural killer cell mediated cytotoxicity, Type I diabetes mellitus, Viral myocarditis