Geminin (GMNN) Rabbit Polyclonal Antibody

CAT#: TA332606

Rabbit anti-GMNN Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using GMNN antibody.

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  Immunohistochemical of paraffin-embedded human liver cancer using GMNN antibody at dilution of 1:200 (200x lens).

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  Immunohistochemical of paraffin-embedded human breast cancer using GMNN antibody at dilution of 1:200 (200x lens).

Specifications

Product Data

• Applications: ICC/IF, IHC, WB
• Recommended Dilution: WB 1:500 - 1:2000;IHC 1:50- 1:200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human GMNN
• Formulation: Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 209
• Gene Name: geminin, DNA replication inhibitor
• Database Link:
  NP_056979
  Entrez Gene 57441 MouseEntrez Gene 291137 RatEntrez Gene 51053 Human
  UniProt ID O75496
• Background: This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16.
• Synonyms: Gem; MGORS6

Reference Data

• Protein Families: Druggable Genome, Stem cell - Pluripotency