CHMP2B Rabbit Polyclonal Antibody

CAT#: TA332667

Rabbit anti-CHMP2B Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using CHMP2B antibody.

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  Immunohistochemical of paraffin-embedded human thyroid cancer using CHMP2B antibody at dilution of 1:200 (400x lens).

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB 1:500 - 1:2000;IHC 1:50- 1:200
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human CHMP2B
• Formulation: Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 213
• Gene Name: charged multivesicular body protein 2B
• Database Link:
  NP_054762
  Entrez Gene 68942 MouseEntrez Gene 25978 Human
  UniProt ID Q9UQN3
• Background: This gene encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. ESCRT-III functions in the concentration and invagination of ubiquitinated endosomal cargos into intralumenal vesicles. The protein encoded by this gene is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes. It is expressed in neurons of all major regions of the brain. Mutations in this gene result in one form of familial frontotemporal lobar degeneration.
• Synonyms: ALS17; CHMP2.5; DMT1; VPS2-2; VPS2B

Reference Data

• Protein Pathways: Endocytosis