PEX5 Rabbit Polyclonal Antibody

CAT#: TA332912

Rabbit anti-PEX5 Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using PEX5 antibody.

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  Immunohistochemistry of paraffin-embedded Human liver injury using PEX5 antibody at dilution of 1:100 (x400 lens).

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  Immunohistochemistry of paraffin-embedded Rat heart using PEX5 antibody at dilution of 1:100 (x400 lens).

Specifications

Product Data

• Applications: ICC/IF, IHC, WB
• Recommended Dilution: WB 1:500 - 1:2000;IHC 1:50 - 1:200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human PEX5
• Formulation: Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 70 kDa
• Gene Name: peroxisomal biogenesis factor 5
• Database Link:
  NP_000310
  Entrez Gene 19305 MouseEntrez Gene 312703 RatEntrez Gene 5830 Human
  UniProt ID P50542
• Background: The product of this gene binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of neonatal adrenoleukodystrophy (NALD), a cause of Zellweger syndrome (ZWS) as well as may be a cause of infantile Refsum disease (IRD). Alternatively spliced transcript variants encoding different isoforms have been identified.
• Synonyms: PBD2A; PBD2B; PTS1-BP; PTS1R; PXR1; RCDP5

Reference Data

• Protein Families: Druggable Genome