RGS18 Rabbit Polyclonal Antibody

CAT#: TA336471

Rabbit Polyclonal RGS18 Antibody

Product Images

Western Blot: RGS18 Antibody TA336471 - Analysis of RGS18 in human lung lysate using this antibody at a dilution of 2 ug/ml.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1-3 ug/ml
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Amino acids 200-218 of human RGS18 (Genebank accession no NP_570138). were used as immunogen.
• Formulation: PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Protein G purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: regulator of G-protein signaling 18
• Database Link:
  NP_570138
  Entrez Gene 64407 Human
  UniProt ID Q9NS28
• Background: Regulators of G-protein signaling (RGSs) are a protein family that can act as GTPase-activating proteins for G(alphai)- and G(alphaq)-class proteins. One of these proteins, RGS18, is a 235 amino acid protein that is closely related to RGS5 (46% identity) and approximately 30-40% identity to other RGS proteins. This protein is expressed in platelet, leukocyte, and megakaryocyte cell lines. Engagement of TLR3 or TLR4 on monocyte-derived DCs potently down-regulates RGS18 and RGS14 without modifying other RGS proteins. A similar pattern of RGS protein expression occurs in immature bone marrow-derived mouse DCs stimulated to mature via TLR4 signaling. The changes in RGS18 and RGS1 expression are likely important for DC function.
• Synonyms: RGS13