GFI1 Rabbit Polyclonal Antibody

CAT#: TA337145

Rabbit Polyclonal GFI-1 Antibody


USD 424.00

5 Days*

Size
    • 100 ug

Product Images

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Specifications

Product Data
Applications IHC, WB
Recommended Dilution Immunohistochemistry, Western Blot: 6-8ug/ml~, Immunohistochemistry-Paraffin: 5ug/ml
Reactivities Human, Mouse, Rat, Bovine, Chicken
Host Rabbit
Clonality Polyclonal
Immunogen A portion of amino acid 280-330 of human Zinc finger protein Gfi-1 was used as the immunogen.
Formulation PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration lot specific
Purification Protein A purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name growth factor independent 1 transcriptional repressor
Background Gfi-1 is a nuclear zinc finger (ZF) transcriptional repressor that plays an important role in hematopoiesis and inner ear development, and has been implicated in lymphomagenesis. The Gfi1 protein expression is regulated by the ubiquitin-proteasome system. It is reported that ubiquitin ligase Triad1 interacts with the DNA-binding domain of Gfi-1. Gfi-1 represses transcription by directly binding to the consensus DNA sequence in the promoters of its target genes. Deficiency of Gfi-1 causes neutropenia and an accumulation of granulomonocytic precursor cells that is reminiscent of a myelodysplastic syndrome in mice.
Synonyms GFI-1; GFI1A; SCN2; ZNF163
Reference Data
Protein Families Druggable Genome, Transcription Factors

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