FKBP51 (FKBP5) Rabbit Polyclonal Antibody

CAT#: TA347128

Rabbit Polyclonal FKBP51 Antibody

Product Images

WB was performed on whole cell lysates from mouse fibroblasts (NIH3T3) and embryonic stem cells (E14Tg2a) with the antibody against mouse FKBP51, diluted 1:500 in BSA/PBS-Tween. The molecular weight marker (in kDa) is shown on the left; the location of the protein of interest (expected size: 51 kDa) is indicated on the right.

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  Determination of the titer To determine the titer, an ELISA was performed using a serial dilution of the antibody against mouse FKBP51. The plates were coated with a mix of the peptides used for immunization of the rabbit. By plotting the absorbance against the antibody dilution (Figure 1), the titer of the antibody was estimated to be 1:9, 400.

Specifications

Product Data

• Applications: ELISA, WB
• Recommended Dilution: ELISA (1:100 ?? 1:500) ; Western blotting (1:500)
• Reactivities: Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-FKBP51 antibody: mouse FKBP51 (FK506 Binding Protein 51), using two KLH-conjugated synthetic peptides containing an amino acid sequence from the central part of the protein
• Concentration: lot specific
• Purification: Whole antiserum from rabbit containing 0.05% azide.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: FK506 binding protein 5
• Database Link:
  NP_004108
  Entrez Gene 14229 Mouse
  UniProt ID Q13451
• Background: FKBP51 (UniProtKB/Swiss-Prot entry Q13451) is a member of the immunophilin protein family, which plays a role in immunoregulation and basic cellular processes involving protein folding and trafficking. It acts as a receptor for FK506 and rapamycin, two immunosuppressants which inhibit T-cell proliferation. FKBP51 is thought to mediate calcineurin inhibition and interacts with progesterone receptor complexes.
• Synonyms: AIG6; FKBP51; FKBP54; P54; PPIase; Ptg-10

Reference Data

• Protein Families: Druggable Genome