AP2 alpha (TFAP2A) Rabbit Polyclonal Antibody

CAT#: TA347649

Rabbit Polyclonal Anti-AP-2 Antibody

Product Images

Western blot analysis on COLO205 cell lysate using AP-2 Antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-1:2000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-AP-2 Antibody: A synthesized peptide derived from human AP-2
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt
• Concentration: lot specific
• Purification: Immunogen affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 49 kDa
• Gene Name: transcription factor AP-2 alpha
• Database Link:
  NP_001035890
  Entrez Gene 21418 MouseEntrez Gene 306862 RatEntrez Gene 7020 Human
  UniProt ID P05549
• Background: AP-2 alpha Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region.
• Synonyms: AP-2; AP-2alpha; AP2TF; BOFS; TFAP2
• Note: AP-2 Antibody detects endogenous levels of AP-2

Reference Data

• Protein Families: Druggable Genome, Transcription Factors