IPP 2 (PPP1R2) Rabbit Polyclonal Antibody

CAT#: TA347792

Rabbit Polyclonal Anti-PPP1R2 Antibody

Product Images

Western blot analysis on Jurkat cell lysate using PPP1R2 Antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-1:2000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-PPP1R2 Antibody: A synthesized peptide derived from human PPP1R2
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt
• Concentration: lot specific
• Purification: Immunogen affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 25 kDa
• Gene Name: protein phosphatase 1 regulatory inhibitor subunit 2
• Database Link:
  NP_006232
  Entrez Gene 66849 MouseEntrez Gene 192361 RatEntrez Gene 5504 Human
  UniProt ID P41236
• Background: PPP1R2 a member of the protein phosphatase inhibitor 1 family. A dopamine- and cyclic AMP-regulated neuronal phosphoprotein. Both dopaminergic and glutamatergic (NMDA) receptor stimulation regulate the extent of DARPP32 phosphorylation, but in opposite directions. Dopamine D1 receptor stimulation enhances cAMP formation, resulting in the phosphorylation of DARPP32; phosphorylated DARPP32 is a potent protein phosphatase-1 inhibitor. NMDA receptor stimulation elevates intracellular calcium, which leads to activation of calcineurin and dephosphorylation of phospho-DARPP32, thereby reducing the phosphatase-1 inhibitory activity of DARPP32.
• Synonyms: IPP-2; IPP2
• Note: PPP1R2 Antibody detects endogenous levels of PPP1R2

Reference Data

• Protein Families: Druggable Genome