EZH2 Rabbit Polyclonal Antibody

CAT#: TA347894

Rabbit Polyclonal Anti-EZH2 Antibody

Product Images

Western blot analysis of EZH2 expression in HEK293 cell lysate

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-1:2000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-EZH2 Antibody: A synthesized peptide derived from human EZH2
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 ?.Stable for 12 months from date of receipt
• Concentration: lot specific
• Purification: Immunogen affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 85 kDa
• Gene Name: enhancer of zeste 2 polycomb repressive complex 2 subunit
• Database Link:
  NP_004447
  Entrez Gene 14056 MouseEntrez Gene 312299 RatEntrez Gene 2146 Human
  UniProt ID Q15910
• Background: Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Compared to EZH2-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.
• Synonyms: ENX-1; ENX1; EZH1; EZH2b; KMT6; KMT6A; WVS; WVS2
• Note: EZH2 Antibody detects endogenous levels of total EZH2

Reference Data

• Protein Families: Druggable Genome, Transcription Factors