AK6 Rabbit Polyclonal Antibody

CAT#: TA349030

Rabbit Polyclonal Anti-TERF2 Antibody

Product Images

Western blot analysis of TERF2 in 293 cell lysate with TERF2 antibody at 1 ug/mL.

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  Immunohistochemistry of TERF2 in human kidney tissue with TERF2 antibody at 5 ug/mL.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IHC: 5 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: TERF2 antibody was raised against a 17 amino acid peptide near the amino terminus of human TERF2.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: TERF2 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 60 kDa; Observed: 69 kDa
• Gene Name: adenylate kinase 6
• Database Link:
  NP_057367
  Entrez Gene 102157402 Human
  UniProt ID Q9Y3D8
• Background: The telomeric repeat binding factor family (TERF1 and TERF2) plays a key role in cellular immortalization and cellular senescence (1). TERF2, as a component of the telomere nucleoprotein complex, is present at telomeres in metaphase of the cell cycle (2). TERF2 is a second negative regulator of telomere length and binds as a dimer to TTAGGG repeats at ends of chromosomes (telomeres), where it blocks inappropriate activation of the ATM/p53 pathway (2,3). TERF1 negatively regulates telomere elongation, while TERF2 protects the chromosome ends by inhibiting end-to-end fusions. Down-regulation of TRF expression in tumor cells may contribute to cell immortalization and malignant progression (4,5).
• Synonyms: AD-004; CGI-137; CINAP; CIP; hCINAP