Corticotropin Releasing Factor (CRH) Rabbit Polyclonal Antibody

CAT#: TA349055

Rabbit Polyclonal Anti-CRH Antibody


USD 484.00

5 Days*

Size
    • 100 ug

Product Images

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Specifications

Product Data
Applications IF, IHC, WB
Recommended Dilution WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
Reactivities Human
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen CRH antibody was raised against a 16 amino acid peptide near the amino terminus of human CRH.
Formulation PBS containing 0.02% sodium azide.
Concentration 1 mg/ml
Purification CRH antibody is affinity chromatography purified via peptide column.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size Predicted: 22 kDa; Observed: 29 kDa
Gene Name corticotropin releasing hormone
Background Corticotropin-releasing hormone (CRH) is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress (1). In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta where it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturitio (2). Marked reduction in this protein has been observed in association with Alzheimer disease (3).
Synonyms CRF; CRH1
Reference Data
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Long-term depression

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.