Corticotropin Releasing Factor (CRH) Rabbit Polyclonal Antibody

CAT#: TA349055

Rabbit Polyclonal Anti-CRH Antibody

Product Images

Western blot analysis of CRH in human placenta tissue lysate with CRH antibody at (A) 1 and (B) 2 ug/mL.

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  Immunohistochemistry of CRH in human brain tissue with CRH antibody at 5 ug/mL.

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  Immunofluorescence of CRH in human brain tissue with CRH antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: CRH antibody was raised against a 16 amino acid peptide near the amino terminus of human CRH.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: CRH antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 22 kDa; Observed: 29 kDa
• Gene Name: corticotropin releasing hormone
• Database Link:
  NP_000747
  Entrez Gene 1392 Human
  UniProt ID P06850
• Background: Corticotropin-releasing hormone (CRH) is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress (1). In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta where it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturitio (2). Marked reduction in this protein has been observed in association with Alzheimer disease (3).
• Synonyms: CRF; CRH1

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Long-term depression